Nova (7-2) struck out five and walked only one while carrying the Yankees to their third straight victory. He allowed a leadoff single to Desmond Jennings in the first and did not give up another hit until Sean Rodriguez reached on a one-out double in the eighth.
Nova came out to start the ninth in a bid to record the second shutout of his career, but he gave up back-to-back triples to start the inning and was removed in favor of Rafael Soriano.
Soriano retired the only three men he faced to pick up his eighth save.
Alex Cobb (2-2) gave up four runs on five hits in seven innings to take the loss.