The only Los Angeles score came on a homer by Albert Pujols, his third of the year and his second in as many games.
Chicago, however, took advantage of six walks by C.J. Wilson (4-4), who gave up four runs on four hits in 3 2/3 innings to take the loss. Three of the runs allowed by Wilson were unearned.
Sale (4-2) surrendered five hits while striking out seven. Three relievers combined to give up one hit over the final 3 1/3 innings.
Los Angeles designated hitter Mark Trumbo went 4-for-4, but the Angels were 0-for-7 with runners in scoring position.