Stuckey and Knight were among six Pistons who reached double figures and gave Detroit a season-high fourth straight home victory.
The Pistons ended the first quarter with a 37-18 lead and Toronto was never able to close the gap significantly after that. Detroit outscored the Raptors 28-16 in the fourth quarter.
DeMar DeRozan led Toronto with 15 points and Andrea Bargnani had eight points in his first game since Jan. 25. Jose Calderon scored 2 points and played 13 minutes before being helped off the court in the second quarter with an apparent sprained ankle.