In addition to the Andino two-shot homer and Reimold's solo shot, the Orioles got a home run from J.J. Hardy and a two-run double from Matt Angle in sending Boston off to its 10th loss in 12 games.
Jeremy Guthrie (9-17) scattered 10 hits, including a Darnell McDonald home run, and four runs over six innings in earning the win. Jim Johnson got three groundouts in the ninth to notch his seventh save.
Kyle Weiland (0-3) allowed just five hits but three were home runs and another was Angle's double. He also walked two while striking out five.
Angle's RBI came in the third inning after Reimold singled and Josh Bell reached on an error. McDonald answered with his sixth home run of the season in the bottom of the third but Andino hit his two-run homer -- coming after a walk -- and Reimold followed with his for a 5-1 lead in the fourth.
David Ortiz scored in the fourth for Boston on a triple by Jarrod Saltalamacchia but Hardy pushed the lead back for four runs with his home run in the fifth.
Boston pulled closed with an RBI double from Adrian Gonzalez and a run-scoring triple from Dustin Pedroia in the fifth and an RBI single by Gonzalez in the seventh.