The Lakers set a franchise record for fewest points allowed in the rout and led by as many as 56 points in the fourth quarter.
Alonzo Gee had 12 points and Ramon Sessions 10 for the Cavaliers, who have lost 11 in a row and 17 consecutive road games.
Los Angeles started the game with a 13-2 run and never looked back. The Lakers led 57-25 at halftime and then shot 70 percent in the third quarter.
Cleveland did not score more than 16 points in any one quarter.