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Oct. 11, 2010 / 12:12 AM

NFL: Philadelphia 27, San Francisco 24

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Philadelphia Eagles Dimitri Patterson (23) intercepts a pass from San Francisco 49ers Alex Smith intended for Ted Ginn in the second quarter at Candlestick Park in San Francisco on October 10, 2010. The Eagles defeated the 49ers 27-24 UPI/Terry Schmitt

Philadelphia Eagles Dimitri Patterson (23) intercepts a pass from San Francisco 49ers Alex Smith intended for Ted Ginn in the second quarter at Candlestick Park in San Francisco on October 10, 2010. The Eagles defeated the 49ers 27-24 UPI/Terry Schmitt | License Photo

SAN FRANCISCO, Oct. 11 (UPI) -- Quintin Mikell recovered a fumble and returned it 52 yards for a score Sunday in the Philadelphia Eagles' 27-24 victory over San Francisco.

Mikell's touchdown off quarterback Alex Smith's miscue early in the final period gave the Eagles a 14-point lead and boosted Philadelphia (3-2) to the win.

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Kevin Kolb, filling in for the injured Michael Vick, completed 21-of-31 passes, gaining 253 yards with a touchdown and no interceptions. He was sacked four times.

Jeremy Maclin hauled down six passes for 95 yards and LeSean McCoy rushed for 92 yards and a TD on 18 carries for the victors.

San Francisco lost a fifth straight game to start a season for the first time in 31 years.

Smith went 25-of-39 passing for 309 yards with three touchdowns but was picked off twice.

Michael Crabtree grabbed nine passes for 105 yards and a score, and Vernon Davis added five receptions for 104 yards and a TD in the 49ers' loss.

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