On the game-winner, Giroux busted down the right-wing side with the puck, stopped at the top of the circle and hit Pronger on the left with a cross-ice pass. The Flyers defenseman tapped it past Blackhawks goalie Cristobal Huet into a half-open net as regulation time was running out.
Simon Gagne and Scott Hartnell also lit the lamp while Michael Leighton stopped 39-of-41 shots for Philadelphia, winners of 13 of the last 15 games against Chicago.
Kris Versteeg and Marian Hossa got goals for the Blackhawks, who fell short in their bid to tie idle San Jose atop the Western Conference standings. The Sharks maintained a two-point lead (95-93) over the Blackhawks.