Clark completed 20-of-31 passes for 240 yards. Royster ran for 41 yards and caught two passes for 61 yards. Graham Zug caught six passes for 79 yards for the Nittany Lions (2-0).
Greg Paulus, a former Duke basketball player starting for Syracuse as a graduate student, was 14-of-20 for 105 yards with one touchdown and two interceptions.
The Orange (0-2) dropped its second straight game to a Big Ten opponent.