Sanchez threw for 167 yards on 15-of-19 passing and scored a rushing TD. Turner had six receptions for 100 yards and Gable gained 108 yards on 10 carries for USC (7-1, 5-1 Pac-10).
USC is on a five-game winning streak and moved ahead of Oregon atop the Pac-10 standings.
Ronnie Fouch was 14-of-33 for 113 yards and three interceptions for the Huskies (0-8, 0-5), whose winless season caused Coach Tyrone Willingham to announce this week he will step down at the end of the season.
The Trojans scored on each of their first six possessions of the game while the Huskies had only two first downs in the first half.