The Chiefs have lost 11 consecutive games over two seasons.
McFadden carried 21 times, gaining 164 yards. Bush had 16 runs for 90 yards and each ran for a score.
Sebastian Janikowski kicked a 56-yard field goal, longest ever for the Raiders (1-1).
Oakland quarterback JaMarcus Russell completed just six passes for 55 yards.
Kansas City quarterback Tyler Thigpen completed 14 of 33 pass attempts with one touchdown and an interception.
Dwayne Bowe had six receptions for 90 yards and Tony Gonzalez caught a touchdown pass for the Chiefs (0-2).