Ordonez hit RBI doubles in the bottom of the first and seventh innings and Polanco hit a two-run single in the fifth.
Polanco and Curtis Granderson both had two hits for the Tigers, who have won five of their last six games.
Closer Todd Jones earned his fourth save.
Izturis hit a two-run double and Chone Figgins added an RBI single in the seventh.
A run scored on Torii Hunter's double-play groundout in the eighth and Vladimir Guerrero had two hits.
The losing pitcher was Darren O'Day (0-1).