Kane and Webb both fired a 69 at the Blackhawk Country Club Friday to stand at 6-under 138 for 36 holes.
Ochoa was alone in third at 139 as she seeks her seventh victory of the year. The No. 1 ranked player in women's golf could move her year's earnings past $3 million this week.
Inkster had the day's low round, a 6-under 66.
First-round co-leaders Inbee Park and Pat Hurst both struggled Friday. Park shot a 75 and was tied for 12th while Hurst had a 76 and was tied for 16th.