The Titans had a chance to win, taking over on their own 20 with 1:37 to play following a punt. Young moved the offense across midfield with less than 30 seconds remaining, but Brandon Jones dropped a third-down pass and Young couldn't escape an Indianapolis blitz on fourth down.
Young finished 17 of 27 for 184 yards with a touchdown and no interceptions. He also ran for 53 yards on six scrambles for the Titans (1-1), who won their opener on the road last week at Jacksonville.
Manning completed 28 of 42 passes with an interception for the Colts (2-0), who have won their opening two games for the third straight season.