Cutler played just two series, but led a 67-yard touchdown march. Ramsey then went 4-for-10 for 45 yards and a touchdown and an interception.
Travis Henry carried five times for 27 yards and a touchdown, and backup fullback Troy Fleming caught a TD pass for Denver.
Shaun Hill completed 13-of-20 pass attempts for 148 yards, while Alex Smith was 4-for-5 for 58 yards passing for the 49ers. Michael Robinson rushed for 25 yards on six attempts and a TD, and Joe Nedney added a pair of field goals for San Francisco.