Busch led 65 of the 102 laps.
The race at the Daytona International Speedway was run in a light rain. It was postponed Friday night because of rain.
"We should have won this thing back in February," said Busch, referring to the Nextel Cup's Daytona 500. "But it all starts here, I guess."
Pole-winner Jason Leffler brought the field to the green flag to start the race. He had to bounce back from a near-disastrous start to finish ninth.