Henin, the French Open champion, defeated Russian Vera Zvonareva 6-3, 6-2. The world No. 1, Henin reached all four Grand Slam finals last season and has now won her last 11 matches, including titles in Dubai and Doha.
Clijsters, making her final appearance in Miami, lost to Chinese Na Li 4-6, 6-4, 6-2 in 1 hour, 55 minutes. Clijsters committed seven double faults and had her serve broken seven times.
Clijsters has announced that 2007 will be her final season on the WTA Tour.