Memphis extended its winning streak to 23 games and hasn't lost since Dec. 20.
North Texas was upset-minded in the early going before Memphis (31-3) took control. The Tigers, seeded second in the South Region, face seventh-seeded Nevada in Sunday's second round. The Mean Green completed its season with a 23-11 record.
Memphis broke a 28-28 tie by scoring the final nine points of the first half. Joey Dorsey started the spurt with a dunk and, after Jeremy Hunt hit a three-point shot, Dozier was able to work inside for two baskets and a 37-28 Tigers' lead.
North Texas got as close as six in the second half but an 8-0 Memphis run that Doneal Mack started with a three-pointer gave the Tigers control.
Keith Wooden scored 16 points and Calvin Watson 13 added for North Texas.