It was the Huskies' eighth consecutive victory.
Before his hometown crowd and with Houston Rockets Coach Jeff Van Gundy in attendance, Okafor also added 14 rebounds in his eighth double-double of the season.
Okafor, the preseason Big East Conference Player of the Year, came in averaging 17.0 points and 11.2 rebounds. But he struggled in Tuesday's rout of Massachusetts, finishing with a season-low six points in 20 minutes.
The 6-9 center made 13 of 19 shots.
Playing their first true road game of the season, the Huskies (11-1) struggled to pull away. They held a 41-33 halftime lead and owned only a one-point advantage midway through the second period.