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Molecule in red grapes lowered insulin

DALLAS, Oct. 16 (UPI) -- A molecule found in the skin of red grapes lowered insulin levels in mice, even those fed a high-fat diet, researchers in Dallas said.

Resveratrol, when injected in the brain, proved effective in lowering insulin levels in mice with Type 2 diabetes, said Dr. Robert Coppari, assistant professor of internal medicine at the University of Texas Southwestern Medical Center.

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"Our study shows the brain plays an important role in mediating resveratrol's anti-diabetic actions, and it does so independent of changes in food intake and body weight," Coppari said.

The study does not conclude that consuming products made from red grapes, such as wine, will alleviate diabetes, Coppari said.

"The amounts of red wine needed daily would surely cause deleterious effects, especially in the liver," he said. "Rather, our study suggests that resveratrol's analogs that selectively target the brain may help in the fight against diet-induced diabetes."

Coppari and his team next plan to study which neurons in the brain mediate the effects of resveratrol.

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