BETHESDA, Md., July 30 (UPI) -- The U.S. National Institute of Environmental Health Sciences has constructed a mouse haplotype map to help identify genes related to environmental disease.
The research involving the DNA of 15 mouse strains commonly used in biomedical studies appears in this week's online issue of the journal Nature. The data now publicly available in a catalog of genetic variants as a haplotype -- a tool that separates chromosomes into many small segments -- marks the first published full descriptive analysis of the Mouse Genome Resequencing and SNP Discovery Project.
"These data allow researchers to compare the genetic makeup of one mouse strain to another, and perform the necessary genetic analyses to determine why some individuals might be more susceptible to disease than another," said Dr. David Schwartz, NIEHS director.
The paper describes in detail the approaches used to identify 8.27 million high quality SNPs -- single nucleotide polymorphisms -- distributed among the genomes of 15 mouse strains. SNPS are single genetic changes, or variations, that can occur in a DNA sequence.
The data are also available at http://www.ncbi.nlm.nih.gov/SNP/.