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Itooka outlived her husband, who died in 1979. Her son, Hiroshi Kai, said his mother liked spending time on her own, climbing mountains.
She didn't slow down after turning 80, completing a Buddhist pilgrimage that included visits to some 33 temples.
She didn't use a walking cane when visiting a shrine after her 100th birthday.
Guinness World Records noted that, in addition to being the oldest human alive today, she is also ranks 23 in the list of oldest humans to ever exist.