"When you've accomplished everything there is to accomplish in your chosen field, what to do?" the auction description states after listing Brady's on-field accomplishments. "If you're Tom Brady, you try your hand at acting."
The lot contains the gray Giorgio Armani T-shirt and white Brooks Brothers boxer shorts worn by the three-time Super Bowl MVP during his cameo appearance in the film. Production tags, photos, scene information and a certificate of authenticity are also included.
Ted 2, released in June 2015, generated $215 million at the box office.
Bidding on the Brady lot will begin Monday, Goldin Auctions said.
The New Jersey-based auction site is also selling a more traditional piece of Brady memorabilia -- an autographed game ball from Super Bowl XLII, which the Patriots lost to the New York Giants, with a starting bid of $1,500.
