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According to Ripley County Cpl. Earl Wheetley, a man was holding a towel on the alleged victim's shoulder.
Wheetley was told the victim and her husband had been arguing and then he shot her.
The 59-year-old suspect was in the trailer and he asked whether his wife was dead after Wheetley handcuffed him.
"I asked Bobby what happened, and he stated: 'I got tired of her and shot her,'" Wheetley said.
The woman was flown to a Tennessee hospital to be treated for her wound.
"Last I heard, she was in stable condition," Sheriff Ron Barnett told the Southeast Missourian.