Combining prescription drugs may trigger serious side effects

By HealthDay News
Combining prescription drugs may trigger serious side effects
Drugs to treat high blood pressure, to thin blood and lower cholesterol are some of the most prescribed drugs in the United States. Photo by Dirk (BeekiĀ®) Schumacher/Pixabay

Many older Americans take a variety of prescription drugs, yet new research suggests that combining various medications is not always wise.

Taking lots of different drugs for different conditions is called "polypharmacy," and a team of researchers set out to find how doctors take this into account in their prescribing. To address this, providers discuss "deprescribing" -- working with patients to cut down on unnecessary or redundant medications.


Drugs to treat high blood pressure, to thin blood and lower cholesterol are some of the most prescribed drugs in the United States, the researchers noted.

Although these medications save lives, they can cause serious reactions when mixed with other drugs.

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To look at prescribing habits, researchers led by Dr. Parag Goyal from Weill Cornell Medicine in New York City and Dr. Timothy Anderson from Beth Israel Deaconess Medical Center in Boston, quizzed 750 geriatricians, general internists and cardiologists.

They got responses from 12 percent to 26 percent of these doctors.

Over 80 percent of the doctors who responded said that they recently considered not prescribing a cardiovascular medication and cited adverse side effects as the most common reason.

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Often doctors are reluctant to halt a drug another doctor has prescribed for fear of stepping on a colleague's turf.


Another reason for not stopping a drug is the patient's desire to keep taking it, the researchers found.

Among geriatricians, 73 percent said they might discontinue a drug that was not expected to help patients who had a short time to live, compared with 37 percent of general internists and 14 percent of cardiologists.

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Also, 26 percent of geriatricians said that they might stop prescribing drugs that affect the ability to think and made decisions, compared with 13 percent of general internists and 9 percent of cardiologists. The report was published Nov. 25 in the Journal of the American Geriatrics Society.

"We hope our study will contribute to advancing deprescribing as a patient-centered strategy that can improve the safety of medication prescribing practice and improve the well-being of older adults," the researchers said in a journal news release.

If you're one of the many who regularly take several medications and are concerned about how they work together, talk it over with your doctor.

But never stop taking a prescribed drug or make changes to your medications without speaking to a doctor first. If you have serious side effects from any drugs you're taking, call 911 immediately, the researchers said.

More information


For more on drug interactions, head to the U.S. Food and Drug Administration.

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