Antidepressants may raise odds of gestational diabetes, study suggests

Steven Reinberg, HealthDay News
The drugs venlafaxine (Effexor) and amitriptyline (Endep) were associated with the highest risk of gestational diabetes, especially when taken for a long time. Photo courtesy of HealthDay News
The drugs venlafaxine (Effexor) and amitriptyline (Endep) were associated with the highest risk of gestational diabetes, especially when taken for a long time. Photo courtesy of HealthDay News

Treating depression during pregnancy can be vital to the health of both mother and child, but new research suggests that taking antidepressants may make a woman more vulnerable to gestational diabetes.

Specifically, the drugs venlafaxine (Effexor) and amitriptyline (Endep) were associated with the highest risk, especially when taken for a long time.


Still, "depression needs to be treated during pregnancy," said study author Anick Berard, research chair of medications, pregnancy and lactation at the University of Montreal.

"If a woman is pregnant and is taking antidepressants, she should not stop by herself, but should have a discussion with her physician to assess the best way forward," she said.

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There are many types of treatments for depression -- antidepressants are only one option, Berard noted.

And because this study looked back at data over time, it can't prove that antidepressants cause gestational diabetes, only that the two appear linked.

But the connection might be that antidepressants affect sugar metabolism. Also, a side effect of antidepressants is weight gain, which is a risk factor for diabetes, Berard and her university colleagues pointed out.

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Venlafaxine is in a class of drugs called serotonin and norepinephrine reuptake inhibitors (SNRIs), and amitriptyline is an older type of drug called a tricyclic antidepressant.


Gestational diabetes can result in overweight babies and longer bouts of labor because the baby can get stuck in the birth canal, the researchers explained.

Also, the infants may be more prone to obesity and diabetes later in life.

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For the study, Berard and her team used the Quebec Pregnancy Cohort, which includes all pregnancies and children born in Quebec between 1998 and 2015.

They looked at nearly 21,000 women with gestational diabetes, comparing them with more than 209,000 women without the condition.

Slightly more than 4 percent of the women with gestational diabetes were taking an antidepressant. These included fluoxetine (Prozac), fluvoxamine (Luvox), paroxetine (Paxil) and sertraline (Zoloft), also known as selective serotonin reuptake inhibitors (SSRIs), along with Effexor or Endep.

Using any of these drugs increased the risk for gestational diabetes by 19 percent, compared with not taking them.

The riskiest drugs were Effexor, which raised the risk 27 percent, and Endep, which increased it by 52 percent, the researchers found. The risk was greater the longer the drugs were taken and if more than one drug was prescribed.

Using the drugs for a short time increased the risk 15 percent, while taking them for a long time raised risk to 29 percent.


These estimates need to be put in perspective, Berard stressed.

"The baseline prevalence of gestational diabetes is between 7 percent and 9 percent, hence a 15 percent increased risk would result in a prevalence of 10 percent, whereas a 52 percent increase would result in a 14 percent prevalence," she said. "Hence, the increases remain small, but above what we would have expected."

The findings were published Oct. 1 in the journal BMJ Open.

Doctors need to be aware that all antidepressants aren't the same when it comes to the risk for gestational diabetes, said Dr. Rahul Gupta, chief medical health officer at the March of Dimes.

It appears the SSRIs carry less risk than other antidepressants, Gupta said. But he believes that the first choice to fight depression during pregnancy should be non-pharmaceutical.

This can include counseling, exercise and other ways to cope with depression without drugs.

But women who need these drugs should be taking them, Gupta said. "Depression and the risk of depression may outweigh the risk of gestational diabetes," he said.

More information

For more on pregnancy and depression, see the March of Dimes.

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