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Exercise may delay rare form of Alzheimer's disease

By HealthDay News

WEDNESDAY, Sept. 26, 2018 -- Regular exercise might delay a rare form of early onset Alzheimer's disease, a new study suggests.

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Researchers found that 2.5 hours of walking or other physical activity a week thwarted mental decline tied to autosomal dominant Alzheimer's disease, or ADAD. This is an inherited form of disease that leads to dementia at an early age.

"The results of this study are encouraging, and not only for individuals with rare genetically caused Alzheimer's disease," said Maria Carrillo, chief science officer for the Alzheimer's Association.

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"If further research confirms this relationship between physical activity and later onset of dementia symptoms in ADAD, then we need to expand the scope of this work to see if it also is true in the millions of people with more common, late-onset Alzheimer's," Carrillo said in an association news release. She wasn't involved in the study.

A team led by Dr. Christoph Laske at the University Hospital of Tubingen in Germany examined data on 275 people who carry a genetic mutation for ADAD. The participants' average age was 38.

The investigators wanted to see if at least 150 minutes per week of walking, running, swimming or other exercise could help delay or slow disease progression.

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It may. Those participants who got more physical activity scored higher on brain function assessments, the study found.

They also had lower levels of key biological markers of Alzheimer's disease in their cerebrospinal fluid, including tau -- a protein that builds up in the brains of people with Alzheimer's.

"A physically active lifestyle is achievable and may play an important role in delaying the development and progression of ADAD," Laske and his team wrote. "Individuals at genetic risk for dementia should therefore be counseled to pursue a physically active lifestyle."

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The World Health Organization and the American College of Sports Medicine recommend the exercise target of 150 minutes a week.

The study was published online Sept. 25 in Alzheimer's & Dementia: The Journal of the Alzheimer's Association.

More information

The U.S. National Institute on Aging has more about Alzheimer's disease.

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