Sections
Log in
Top News
U.S. News World News Featured Voices
Odd News
Entertainment
Movies Music TV
Sports
Soccer NFL NBA MLB NHL Golf Horse Racing Tennis Col. Football Col. Basketball
Photos
News Entertainment Sports Features Archives
More...
Defense Featured Science Health Archive Almanac
About Feedback
About Feedback
Search
Trending
'El Chapo'
Jussie Smollett
Plastic pollution
Trampoline break
Lottery
Syria troops
Jeffrey Epstein
Michael Cohen
Terror plot
Measles
Doorbell cam
Health News
July 20, 2018 / 12:21 PM

'Concussion pill' using cannabis shows promise

By
Allen Cone
St. Louis Rams quarterback Marc Bulger lays on the turf after being sacked against the Seattle Seahawks in St. Louis on November 25, 2007. Bulger left the game with a concussion and was transported to an area hospital. Researchers are developing a so-called "concussion pull" that involves medical cannabis. Photo by Bill Greenblatt/UPI | License Photo

July 20 (UPI) -- A "concussion pill" under development in Miami using cannabis is showing progress for treatment of traumatic brain injuries.

In a pre-clinical study, the combination of a hemp-derived cannabinoid and an NMDA amino acid anesthetic is showing improved cognitive function in rodents with traumatic brain injuries compared with individual components.

The project is a joint collaboration with the University of Miami Miller School of Medicine, The Miami Project to Cure Paralysis and Scythian Biosciences Corp. of Toronto.

"The results were statistically significant and encouraging," Scythian's Jonathan Gilbert, who manages the University of Miami partnership, told UPI. "This evidence strongly suggests further testing is warranted on medical cannabis' potential in the treatment of trauma to the brain."

RELATED Military personnel, football players show similar signs of CTE in scans

Scythian, a pre-clinical research and development company developing drug therapies, gave a $16 million grant to the university in 2016. Scythian is attempting to be the front-runner in the medical marijuana industry, including developing the first accepted drug regimen for the treatment of concussion.

"The potential is enormous and extraordinary," Gilbert said. "It may someday be mandatory equipment on the sidelines of every football, baseball and soccer game, from youth leagues to professional organizations, ready to protect people of all ages from the brain's immediate inflammatory response to trauma. It could also become standard treatment in emergency rooms and ambulances so first responders can administer it to patients within the 'golden hour' after an injury: a critical window of opportunity."

In the pre-clinical study, there were no adverse effects from the combination therapy or the individual components.

RELATED Simple cognitive test could help with concussion assessments

"There needs to be more systematic research in this field in order to study the neuroprotective properties of CBD, and to improve treatment for those sustaining mild to moderate traumatic brain injury and concussion," Dr. Gillian A. Hotz, professor of neurological surgery, and director of the KiDZ Neuroscience Center at The Miami Project and the UM Sports Medicine Institute concussion program, said in a press release.

In Phase 2 research, a few humans will likely be administered the compounds in pill form to a control group and two groups of TBI patients, acute and chronic.

The third phase will be a full-scale clinical trial over the next three years if the treatment is determined to be deemed safe and effective. The researchers plans to study the effectiveness in other injury models.

RELATED After concussion, legs may be at risk, too

Then it would need to be evaluated by the U.S. Food and Drug Administration as an effective therapeutic treatment for those suffering from severities of TBI and concussion.

In June, the FDA approved for the first time a drug derived from marijuana -- to treat epilepsy -- as well as its first medication of any kind for Dravet syndrome. Epidiolex was approved for the treatment of seizures associated with two rare and severe forms of epilepsy -- Lennox-Gastaut syndrome and Dravet syndrome.

"The implications for the study are extraordinary," Dr. Michael Hoffer, director of the Vestibular and Balance Program in Miami's Department of Otolaryngology, said. "Having such a large, multidisciplinary team of neuroscience experts attaching themselves to research that could change the outcome of TBI and concussion care is the opportunity researchers have been looking for to curb the growing trend of concussion."

RELATED Study finds many concussion patients don't follow-up

Besides athletes getting concussions, there have been 370,688 traumatic brain injuries diagnosed among U.S. military members from 2000 to 2017, according to Defense and Veterans Brain Injury Center. Among those cases, 305,140 were listed as mild.

Short-term effects of concussions include headaches and dizziness, as well as an increased risk for longer-term chronic medical problems, including disorders of attention, memory, anxiety, depression and dementia.

"One thing has eluded us -- a clinically proven medication to treat concussion," Hotz said. "Whether or not this study leads to a pill that could treat concussion, this type of research will pave the way for UM and other researchers to better manage concussion. It's a privilege to help lead this journey."

Gilbert said the treatment likely will be in pill form.

"The University of Miami believes it will be a pill, however we are open to any type of delivery method -- a strip, ingestion through the nose, intravenous uptake, etc," he said. "Though we don't have confirmation on the treatment's delivery method, we are working under the assumption that it is going to be a pill."

  • Topics
  • Food and Drug Administration
  • Marijuana
  • Medical Marijuana
  • John Walker
Follow us on Facebook, Twitter and Instagram for more UPI news and photos.

Trending Stories

Electric bikes could improve brain function in older people
Weight-loss surgery could benefit sex life, study says
Report: The number of cancer survivors grows as oncologists dwindle
New recommendation could cut costly UTI tests in half, study says
Study participants likely to lie when they get paid, research shows

Photo Gallery

 
Beijing celebrates annual Lantern Festival

Latest News

'Holmes & Watson,' Trump & Conway win Razzie Awards
Famous birthdays for Feb. 23: Daymond John, Dakota Fanning
On This Day: U.S. Marines raise flag on Iwo Jima
UPI Almanac for Saturday, Feb. 23, 2019
Kansas City Chiefs sign Sammie Coates, E.J. Manuel, two more
 
Back to Article
/
Back to top
About UPI Contact Feedback Advertisements Submit News Tips
Copyright © 2019 United Press International, Inc. All Rights Reserved.
Terms of UsePrivacy Policy