Gout linked to increased heart-attack risk

Aug. 2, 2006 at 2:13 PM
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PITTSBURGH, Aug. 2 (UPI) -- University of Pittsburgh School of Medicine researchers find that people with gout are at increased risk of having a heart attack.

This is the first study to show that among men with no previous history of coronary artery disease, gout is a significant independent risk factor of heart attack, according to lead author Dr. Eswar Krishnan.

The study examined data from 12,866 men who were enrolled for a mean of 6.5 years in the Multiple Risk Factor Intervention Trial, a randomized primary cardiovascular disease prevention trial conducted by the National Heart, Lung and Blood Institute.

Over the study period, 1,123 individuals developed gouty arthritis.

During the course of the study, 1,108 heart attacks occurred in the group with gout, or 10.5 percent, and 990 events in the group without gout, or 8.43 percent. Of the 1,108 myocardial infarctions, 246 were fatal.

The absolute magnitude of the relative risk for the presence of gout was not high, yet the odds ratio associated with gout was relatively high compared to other risk factors in this study, according to the study published in the journal Arthritis & Rheumatism.

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