The pair confirmed Friday they are writing and will star in the show.
It is expected to debut in 2022.
Francesca Sloane -- whose credits include Atlanta and Fargo -- is co-creator and will be the showrunner for the new Mr. & Mrs. Smith.
ABC made a TV pilot inspired by the film for the 2006-07 season, but it was not picked up to series.
Martin Henderson and Jordana Brewster played the title roles.