Kimmel recently announced he was taking the summer off from his show to spend more time with his family.
He said various stars would fill in for him -- taping the show from their homes -- while he was gone.
Live! has been broadcast remotely due to social-distancing practices enacted to slow the spread of the coronavirus.
Shortly after making his vacation announcement, Kimmel apologized for using blackface in his comedy years ago, following pressure from critics on social media.
Appearing as well in Tuesday's episode will be Bubba Wallace -- a Black NASCAR driver who made headlines when he was believed to be the target of a hate crime. The FBI investigated the incident and determined it to be a misunderstanding.
On Thursday, he will interview entertainer Billy Porter.