Garth & Trisha Live! is scheduled to air on the network at 9 p.m. ET.
It will be filmed without a live studio audience and will involve a minimal crew practicing social distancing, CBS said in a press release.
"We're seeing how big things can be when we all do them as one. In addition to the special, we and CBS will donate $1 million to charities to be determined, combating the COVID-19 virus," the couple said in a statement Sunday.