The Upshaws is a multi-camera comedy that follows a working-class, African-American family in Indiana who are struggling to make it work.
Fields, best known for starring in sitcoms The Facts of Life and Living Single, will star as Regina Upshaw who is the wife of Bennie (Epps) and the mother to their three children.
Sykes will appear as Regina's sister Lucretia. Regina works in medical billing at a hospital while Bennie runs a garage with Lucretia acting as his silent partner.
Netflix released on Twitter Wednesday a selfie of Fields and Epps holding up cards showcasing their roles.
Sykes and Epps are serving as executive producers with Sykes also joining Regina Hicks as co-showrunner.