The show will end its six-season run on Dec. 8.
"Members of the World Cup champion U.S. Women's Soccer team -- Crystal Dunn, Allie Long, Ashlyn Harris and Ali Krieger -- visit the White House to help Elizabeth (Téa Leoni) kick off a new landmark political initiative," a press release from the network said. "Cicely Tyson guest stars as Flo Avery, who was born the day women were granted the right to vote, and joins the soccer stars at the White House. Tyne Daly guest stars as Sen. Amy Ross from Ohio, who opposes the initiative."
Frampton, who previously appeared in Season 5 of the political drama, will return to perform during a McCord family celebration.
The Madam Secretary ensemble also includes Tim Daly, Željko Ivanek, Patina Miller, Erich Bergen, Wallis Currie-Wood and Kevin Rahm. The show follows the title character -- Leoni's Elizabeth McCord -- as she juggles international diplomacy with being the married mother of three children.