Sept. 17 (UPI) -- Grey's Anatomy will feature Alyssa Milano and Holly Marie Combs as guest stars in Season 16.
ABC announced on the show's official Twitter account Monday that Milano and Combs, who co-starred on The WB series Charmed, will appear in the new season.
"We're excited to have the charmed ones @Alyssa_Milano and @H_Combs guest-starring on #GreysAnatomy! #CastFromThePast," the post reads.
Entertainment Weekly said Milano and Combs will guest star in Grey's Anatomy's Oct. 7 episode, part of the show's "Cast from the Past" week. The pair will play sisters of a brain dead hospital patient who must decide whether to keep their sister on life support.
Combs said Monday on Twitter that the episode will give fans "all the feels and I mean ALLLLLLLLLLLLLLLLL." She also shared a photo on Instagram with Milano and Charmed producers Krista Vernoff and Andy Reaser, who now work on Grey's Anatomy.
"Reunited. And we couldn't be happier. @kristavernoff @andyreaser well... there were some tears... just some. @greysabc #CastFromThePast," Combs captioned the post.
Milano and Combs played Piper and Phoebe Halliwell on Charmed, which had an eight-season run from 1998 to 2006. A reboot starring Madeleine Mantock, Melonie Diaz and Sarah Jeffery will premiere a second season Oct. 11 on The CW.