The E! series released a Season 16 promo Thursday showing Kardashian crying after Thompson's night with Jordyn Woods.
"I am broken by so many things," she says in the clip.
The teaser also shows Jenner, who was best friends with Woods before the scandal.
"Just know I love you," Jenner tells Kardashian.
Kardashian is parent to 13-month-old daughter True with Thompson, who previously cheated in 2017 during her pregnancy. Kardashian grew emotional during a confessional shot in the trailer.
"I'm not just a TV show. Like, this is my life," she says.
Thompson and Woods spent a night partying together in February. Woods said on Red Table Talk in March Thompson kissed her as she left his house early the next morning.
"On the way out, he did kiss me," Woods said. "No passion, no nothing ... It was like a kiss on the lips. No tongue kiss, no nothing."
"I didn't know how to feel," she added. "I walked out immediately after ... I was in shock. I was more so like, 'Did this really [happen]?' I was like, 'Hmm, let's pretend that didn't happen.'"