They both earned their honors for their work on NBC's Saturday Night Live -- Chappelle for hosting and playing multiple characters in sketches and McCarthy for hosting and playing former White House Press Secretary Sean Spicer.
Alexis Bledel won the award for guest actress in a drama series for her performance in Hulu's The Handmaid's Tale and Gerald McRaney was named outstanding guest actor in a drama series for his work in the pilot episode of NBC's This Is Us.
HBO won a leading 16 Creative Arts Emmys.
Westworld picked up the prizes for interactive media; sound mixing for an hour-long drama or comedy series; special visual effects; and hair-styling and makeup (non-prosthetic) for a single-camera series; while The Night Of won for cinematography for a limited series or movie; sound editing for a limited series, movie or special; sound mixing for a limited series or movie; and single-camera picture editing for a limited series or movie.
Big Little Lies earned the trophies for for music supervision; casting for a limited series, movie or special; and contemporary costumes for a series, limited series or movie. Veep scored for casting for a comedy series; cinematography for a single-camera, half-hour series; and production design for a narrative program -- half hour or less.
The cable network's Once Upon a Sesame Street Christmas was also named outstanding children's program.
Streaming service Netflix came in second with 11 Emmy wins. Stranger Things took the honors for main title design; main title theme music; casting in a drama series; single-camera picture editing for a drama series; and sound editing for a series.
The Crown won for period/fantasy costumes for a series, limited series or movie; and production design for a narrative period program -- one hour or more -- while Master of None won for single-camera picture editing for a comedy.
The Ranch won for cinematography for a multi-camera series; House of Cards won for original dramatic score; and Luke Cage won for stunt coordination for a drama series, limited series or movie.
Emmy Awards for the main acting and show categories are to be handed out this coming Sunday in Los Angeles. Stephen Colbert is to host the ceremony.