Set to debut in 2018, the seven-episode series is executive-produced by Lorne Michaels. Simon Rich created it and will serve as showrunner.
"Having Daniel Radcliffe and Owen Wilson join the TBS family is proof of the continued evolution of this comedy brand as the home of the most creative minds in the business," Brett Weitz, executive vice president of original programming for TBS, said in a statement Wedensday. "Owen Wilson has long been a comic genius, and Daniel's performance in last year's Swiss Army Man really proved that there's a sophisticated comedian under the surface of those brilliant dramatic chops. Simon and Lorne are total pros in walking the tightrope between reality and ridiculousness, and they do it with a lot of heart and wit."
TBS said the first season of Miracle Workers will be "a Heaven-set, workplace comedy based on Rich's book What in God's Name."
Harry Potter icon Radcliffe will play Craig, "a low-level angel responsible for handling all of humanity's prayers," while Cars 3 star Wilson will play Craig's boss, "God, who has pretty much checked out to focus on his favorite hobbies."