TBS' Los Angeles-based Conan will be broadcast from Harlem's famed Apollo Theater Monday through Thursday.
The week of episodes will kick off the beginning of Conan's eighth year on the cable television network. It also marks the show's sixth out-of-the-studio trip in the past 18 months and its second excursion to New York.
Previous trips have taken Conan to North Korea, Armenia and the United States Air Force Base in Doha, Qatar, where O'Brien was accompanied by First Lady Michelle Obama. O'Brien became the first American late-night host to shoot in Cuba in more than 50 years in the spring of 2015.
Episodes of the show have also been taped in Chicago, Dallas, Atlanta and San Diego Comic-Con.