Taking place Wednesday, the actress and late night host were given a character and a scenario to play out on the spot involving the answering of a telephone in the most "sincerely dramatic way possible."
Naturally, Henson was tasked with playing her character Cookie from Fox's hit music drama Empire, as she finds out from NASA that she will be stranded out in space for six more months.
"Lucious!," the actress screamed out referencing Cookie's ex-husband from the show played by Terrance Howard. "Oh, it's Houston. What's wrong? I'm not coming home for what?" she continued in character.
"Look I got a nail appointment, honey. I haven't been waxed. I'm looking like a woolly mammoth up here," Henson said to the delight of Fallon and the audience.
Other scenarios included Fallon recommending a show to watch on Netflix to Queen Elizabeth while constipated while Henson portrayed talking to the husband of a best friend who was calling to explain why he wasn't in the delivery room for the birth of their triplets.
Henson will be seen as Cookie once again when Empire returns March 30 on Fox.