The comedy follows three stressed-out moms with seemingly perfect lives who go on a "wild, un-momlike binge of freedom, fun and self-indulgence" before clashing with the PTA head and her clique of overachieving mothers.
"Jon Lucas and Scott Moore are masters at creating relatable characters that audiences instantly embrace, and then putting them in hilarious, real-life situations for great comedic results," STX president Oren Aviv said in a statement.
"This film provides the rare opportunity for a half-dozen strong female lead roles, and we are thrilled to have assembled an exceptional cast," he added. "We can't wait to start production and be part of the magic this team will bring to the screen."
Kunis is mother 1-year-old daughter Wyatt with husband Ashton Kutcher, while Bell shares 2-year-old daughter Lincoln and 10-month-old daughter Delta with husband Dax Shepard. Applegate is mom to 4-year-old daughter Sadie with husband Martyn LeNoble.