Zombie will also direct. No casting or premiere date have been announced yet.
Created and written by Joey Slamon, the series "takes places over a single night in the home of a wealthy family under attack by a murderous cult," press notes said.
"We're excited to work in partnership with Rob Zombie as well as Mila Kunis and her Orchard Farm Productions associates Susan Curtis, Cami Curtis and Lisa Sterbakov on this horror-comedy series," Starz Managing Director Carmi Zlotnik said in a statement Tuesday.
Kunis is best known for her work on TV's That '70s Show, and the films Ted, Black Swan and Jupiter Ascending.
Zombie is a rock musician and filmmaker. His screen credits include House of 1,000 Corpses, The Devil's Rejects and Halloween.