Described as "a comedic, soul-searching examination of our pursuit of happiness and why it continues to be so elusive," the series was created, written and executive produced by critically acclaimed author and regular This American Life contributor Shalom Auslander.
The Happyish series order was announced Monday by the cable network's president David Nevins.
"Shalom has a unique comedic voice. He is smart, provocative and thoughtful. I know he's going to make viewers laugh, but he's also going to push a few buttons while doing it," Nevins said in a statement.
Happyish is scheduled to premiere April 26, immediately after a Season 7 episode of Nurse Jackie. It will be followed by the Season 2 premiere of Penny Dreadful.