Lange won Golden Globe and Screen Actors Guild awards for her work on the haunted-house drama.
Murphy previously said Season 2 will feature a new cast and setting, with the possibility of a few familiar faces from Season 1 coming back.
Interviewer Andy Cohen asked Murphy on TV's "Watch What Happens Live" Monday night whether Lange will make an appearance on the show next season, to which Murphy replied "yes."
E! News said it is unclear whether the actress will reprise her role of Constance Langdon, who was left to raise her demonic grandson in the Season 1 finale, or a different character.