Reese Witherspoon, Oprah Winfrey attend 'A Wrinkle in Time' premiere (20 images)

Cast members attend the premiere of the fantasy "A Wrinkle in Time" in Los Angeles on Monday. The story begins after the disappearance of Meg's scientist father, when three peculiar beings send Meg, her brother, and her friend to space in order to find him. Photo by Jim Ruymen/UPI

Cast member Reese Witherspoon plays Mrs. Whatsit in the film.

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Cast member Oprah Winfrey plays Mrs. Which in the film.

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Cast member Mindy Kaling plays Mrs. Who in the film.

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Director Ava DuVernay attends the premiere.

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