Cabello won a leading four awards on Sunday, including Best Artist, Best U.S./Worldwide Act, Best Video and Best Song for her hit single "Havana" featuring Young Thug.
Nicki Minaj was also a big winner, earning Best Look and Best Hip-Hop. The rapper and Little Mix kicked the show off by performing "Woman Like Me."
Dua Lipa won the award for Best Pop, Cardi B won for Best New Artist, Shawn Mendes won for Best Live, 5 Seconds of Summer won Best Rock, Panic! At The Disco won Best Alternative, and BTS won Biggest Fans, among others.
Jackson performed three of her hits, including "Made For Now," "All For You" and "Rhythm Nation" amongst fiery explosions and a number of backup dancers, before receiving the Global Icon Award.
Jackson spoke out against gender inequality and asked for female voices to be heard in her acceptance speech.
"Tonight, I feel moved to speak for women's voices who have been stifled. I am one of those women. Women who have been gagged, both literally and emotionally. Women who have been abused. Women who have been intimidated. Women who have lived in fear. I stand with you. You are my sisters," Jackson said.
"Tonight, I carry the hope that a new world is emerging. A world in which caring people, male as well as female, will no longer tolerate gender inequality," she continued. "Women, our voices will be heard. We will be heard when we speak out for justice."