The festival, which promises four days of music, culture and entertainment, will take place from July 5-8 at the Louisiana Superdome in New Orleans across five stages.
Jackson and Blige will be joined by other headlining acts including Miguel, Fantasia and Xscape along with a set featuring Erykah Badu and Jill Scott with Snoop Dogg and other guests in a special curation by The Roots.
Daniel Caesar, H.E.R., Kelela, Ro James, DVSN, 112, Mali Music, Kevin Ross, Marsha Ambrosius and Teddy Riley's New Jack Swing Experience featuring Wreckx-n-Effect, BlackStreet and Guy will also be performing along with host Roy Wood Jr.
Weekend ticket packages are on sale starting at $150.
The 2018 Essence Festival will also feature a Superlounge that offers a DJ curated experience featuring sets by actor Idris Elba and MC Lyte.