The tour will consist of the pair performing six shows across three cities starting with performances at Radio City Music Hall in New York City on March 2-3.
Weir and Lesh will then be heading to the Wang Theater in Boston from March 7-8 followed by shows at the Chicago Theatre in Chicago on March 10-11.
Tickets will be available through Ticketmaster starting Dec. 15 at 10 a.m. local time.
"We're going to play everything we can think of," Lesh said to Billboard of what fans can expect the duo to perform. "We''re going to do his stuff, we're going to do my stuff, we're going to play Jerry's stuff, we'll do Grateful Dead stuff and we'll do covers. We're going to try and play everything we've ever played together and maybe some new stuff too."