The 30-year-old singer and 38-year-old rapper confirmed as much on social media after Billboard announced the news Friday.
"Me & my boy Ludacris will be hosting the @BBMAs on ABC 5/22. Its always lit when us two #ATLiens get together!" Ciara tweeted.
"It is my honor to host the Billboard Music Awards for the third year and a pleasure to host with my good friend Ciara," he said in a statement. "I'm looking forward to another great show in a new and exciting venue."
"The Billboard Music Awards is one of the best awards show to honor chart success," Ciara added. "I look forward to sharing the stage with [Ludacris] on this special night. It will definitely be a night to remember!"
Ciara and Ludacris have collaborated on the songs "Oh," "High Price" and "Ride," all of which debuted on the Billboard Hot 100. The singer released her album Jackie in May, while Ludacris debuted Ludaversal last March.
Billboard will announce this year's nominees on the Monday, April 11 episode of Good Morning America. The 2016 ceremony will air May 22 at 8 p.m. ET on ABC.