The clip, released on Wednesday, features the iconic British spy coming out of retirement for a new mission.
Bond finds himself reuniting with old faces such as Madeleine Swann (Lea Seydoux), the villainous Blofeld (Christoph Waltz), M (Ralph Fiennes), Q (Ben Whishaw), Felix Leiter (Jeffrey Wright) and Moneypenny (Naomie Harris).
"James Bond. License to kill, history of violence. I could be speaking to my own reflection only your skills die with your body. Mine will survive long after I'm gone," Safin says. "History isn't kind to men who play god," Bond replies.
Also joining in on the action is Nomi (Lashana Lynch), a fellow agent who wants Bond to stay out of her way.
The trailer ends with Bond using mounted guns on his car to escape from a precarious situation.
No Time To Die, from director Cary Joji Fukunaga, is set for release April 3 in the U.K. and April 8 in the U.S.
"In No Time To Die, Bond has left active service and is enjoying a tranquil life in Jamaica. His peace is short-lived when his old friend Felix Leiter from the CIA turns up asking for help. The mission to rescue a kidnapped scientist turns out to be far more treacherous than expected, leading Bond onto the trail of a mysterious villain armed with dangerous new technology," reads the synopsis.