The streaming service released a first trailer for the romantic comedy Wednesday featuring Davis as Kate Conrad, a newly-single woman, and Lowe as Derek Holliston, a safari pilot.
The preview shows Kate (Davis) help Derek (Lowe) save a baby elephant during her trip to Zambia, Africa. The pair flirt as they help nurse the elephant back to health at a wildlife sanctuary.
"Kristin Davis + Rob Lowe + baby elephants = rom-com dreams coming true!" Netflix tweeted Wednesday.
Holiday in the Wild premieres Nov. 1. Netflix shared a poster and first look at the film Tuesday.
Davis herself is wildlife activist who helped rescue an orphaned elephant during a 2009 trip to Kenya. She shared a throwback photo of herself feeding the elephant Monday on Instagram.
"Chaimu (named after the lava flow we found her in among theChyulu Hills in Kenya) is now living a wild life in beautiful Tsavo National Park," the star said.
Davis and Lowe previously co-starred in the 1999 miniseries Atomic Train. Davis is known for playing Charlotte York on Sex and the City, while Lowe portrayed Sam Seaborn on The West Wing.